|
|
leukotriene_C4 <=> leukotriene_A4 + glutathione
|
4.4.1.20
leukotriene-C4 synthase
|
–
|
BMK
|
|
BRENDA:
BR48007
KEGG:
R03059
MetaCyc:
LEUKOTRIENE-C4-SYNTHASE-RXN
SABIO-RK:
8569
|
|
|
|
leukotriene_A4 + H2O <=> leukotriene_B4
|
3.3.2.6
leukotriene-A4 hydrolase
|
–
|
MK
|
|
BRENDA:
BR48209
KEGG:
R03057
MetaCyc:
LEUKOTRIENE-A4-HYDROLASE-RXN
SABIO-RK:
2902
|
|
|
|
(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate <=> leukotriene_A4 + H2O
|
1.13.11.34
arachidonate 5-lipoxygenase
|
–
|
MK
|
|
BRENDA:
BR49526
KEGG:
R03058
MetaCyc:
RXN-8647
|
|
|
|
arachidonic_acid + O2 <=> leukotriene_A4 + H2O
|
1.13.11.31
arachidonate 12-lipoxygenase
1.13.11.34
arachidonate 5-lipoxygenase
|
–
–
|
|
|
BRENDA:
BR50346
KEGG:
R08527
SABIO-RK:
14177
|
|
|
|
leukotriene_A4 + H2O <=> (5S,6S)-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic_acid
|
3.3.2.6
leukotriene-A4 hydrolase
|
–
|
|
|
BRENDA:
BS361334
SABIO-RK:
14022
|
|
|
|
leukotriene_A4 + O2 + reduced_acceptor <=> (5S,7E,9E,11Z,13E,15S)-15-hydroperoxy-5-hydroxyicosa-7,9,11,13-tetraenoate + acceptor
|
1.13.11
|
–
|
M
|
|
MetaCyc:
RXN-20577
|
|
|
|
leukotriene_A4 + O2 <=> lipoxin_A4
|
1.13.11.31
arachidonate 12-lipoxygenase
|
–
|
|
|
BRENDA:
BS440310
|
|
|
|
(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate + O2 <=> leukotriene_A4
|
1.13.11.34
arachidonate 5-lipoxygenase
|
–
|
|
|
BRENDA:
BS288902
|
|
|
|
5-hydroperoxy_fatty_acid + O2 <=> leukotriene_A4
|
1.13.11.40
arachidonate 8-lipoxygenase
|
–
|
|
|
BRENDA:
BS288867
|
|
|
|
leukotriene_A4 + H2O <=> L-arginine + leukotriene_B4
|
3.4.11.6
aminopeptidase B
|
–
|
|
|
BRENDA:
BS382210
|
|
|
|
5-hydroperoxyeicosatetraenoic_acid <=> leukotriene_A4 + H2O
|
1.13.11.34
arachidonate 5-lipoxygenase
|
–
|
|
|
BRENDA:
BS394667
|
|
|
|
leukotriene_A4 + H2O <=> leukotriene_B4 + (5S,12R)-dihydroxy-6,10-trans-8,14,cis-eicosatetraenoic_acid
|
3.3.2.6
leukotriene-A4 hydrolase
|
–
|
|
|
BRENDA:
BS361335
|
|
|
|
leukotriene_A4 + H2O <=> (5S,6S)-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic_acid + leukotriene_B4 + (5S,12R)-dihydroxy-6,10-trans-8,14,cis-eicosatetraenoic_acid
|
3.3.2.6
leukotriene-A4 hydrolase
|
–
|
|
|
BRENDA:
BS361336
|
|
|
|
leukotriene_A4 + H2O <=> 5,6-dihydroxy-7,9,11,14-eicosatetraenoic_acid
|
3.3.2.10
soluble epoxide hydrolase
|
–
|
|
|
BRENDA:
BS378704
|
|